Immunotherapy is better than chemotherapy as firstline treatment for advanced head and

first_imgReviewed by James Ives, M.Psych. (Editor)Oct 23 2018Immunotherapy on its own is better than aggressive chemotherapy as a first-line treatment for advanced head and neck cancer, according to surprising new data from a major phase III clinical trial.Patients lived for longer and had far lower rates of side-effects if they took the immunotherapy drug pembrolizumab than those who received an ‘extreme’ combination of two chemotherapies and a targeted drug.People with an immune hallmark called PD-L1 in their tumours did particularly well on pembrolizumab – living for around 40 per cent longer.And while only around a fifth of patients overall responded to pembrolizumab, those who did so often did spectacularly well – with a median length of response of 20.9 months compared with only 4.2 months with aggressive chemotherapy.The trial was led in the UK by a team at The Institute of Cancer Research, London, and The Royal Marsden NHS Foundation Trust, and involved 206 research centres worldwide.Its findings could in future see immunotherapy become a standard, first-line treatment for advanced head and neck cancer, and spare many patients the side-effects associated with combination chemotherapy.The study is being presented at the European Society for Medical Oncology (ESMO) Congress 2018 in Munich today (Monday), and was sponsored by Merck & Co., Inc.Patients would normally be given aggressive chemotherapy if diagnosed at an advanced stage when the cancer has begun to spread to try to get rid of all the cancer cells as quickly as possible.But the new trial sought to see if immunotherapy, in combination with chemotherapy or on its own, could be a more effective and kinder option.The researchers randomly assigned 882 patients in equal numbers to one of three treatment groups – receiving the ‘extreme’ chemotherapy combination, and the immunotherapy pembrolizumab with platinum chemotherapy or on its own.Patients with high levels of the immune marker PD-L1 in their tumours received the biggest benefit from pembrolizumab – living for a median of 14.9 months after diagnosis compared with 10.7 months with the aggressive combination.But patients with lower levels of PD-L1 also saw benefit, living 12.3 months taking pembrolizumab compared with 10.3 for those who received the combination.Importantly, only 17 per cent of patient experienced serious side-effects with pembrolizumab, compared with 69 per cent of those taking the ‘extreme’ therapy.The only downside to pembrolizumab on its own was that fewer people in total responded. Even in the group with high levels of PD-L1, 23 per cent of patients who received the treatment responded, compared with 36 per cent for chemotherapy.Related StoriesAdding immunotherapy after initial treatment improves survival in metastatic NSCLC patientsHow cell-free DNA can be targeted to prevent spread of tumorsStudy reveals link between inflammatory diet and colorectal cancer riskThe response rate was higher, at 36 per cent, for patients who received platinum chemotherapy alongside pembrolizumab – but these patients had the same high rate of side-effects as those on the aggressive chemotherapy combination.Pembrolizumab is an immune checkpoint inhibitor that targets PD-L1 on the surface of cancer cells. Blocking PD-L1 in this way takes the ‘brakes’ off the immune system, setting it free to attack cancer cells.The findings are consistent with previous studies of checkpoint inhibitor immunotherapies and illustrate the pros and cons of these drugs – their excellent responses in some patients, but the fact that only a minority of patients respond.Professor Kevin Harrington, Professor of Biological Cancer Therapies at The Institute of Cancer research, London and Consultant Clinical Oncologist at The Royal Marsden Foundation Trust, said:”Our study has shown that the immunotherapy pembrolizumab on its own is better than an aggressive triple-whammy of two types of chemotherapy plus a targeted drug as first-line treatment for advanced head and neck cancer.”We couldn’t believe it when we saw the results. None of us expected pembrolizumab on its own to work so well in some of these patients – and it raises the prospect that we could spare some people chemotherapy altogether.”The study could have major implications for the treatment of advanced head and neck cancers – taking immunotherapy from a last resort to the treatment we turn to first for some patients. The trial is still ongoing, but we expect some patients to go on to live for years longer than they would have done had they received standard chemotherapy.”Professor Paul Workman, Chief Executive of The Institute of Cancer Research, London, said:”We’re used to seeing immunotherapy trialled in patients who have exhausted other options – but this trial has shown its true potential as a smarter, kinder and more effective first-line treatment for cancer, where it can have the biggest impact on a patient’s life.”This trial showed the benefits of immunotherapy in head and neck cancer, but I’m optimistic that the same will hold true for other cancers. We now need to do two things to ensure more patients can benefit from immunotherapy – develop ways of getting these drugs to work in a higher proportion of patients, and come to an agreement over the cost of these drugs to make them more affordable for the NHS.”Source: https://www.icr.ac.uk/news-archive/esmo-2018-immunotherapy-effective-as-first-line-treatment-for-advanced-head-and-neck-cancerlast_img read more

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NIH extramural research chief Sally Rockey said that until now,Hillary Clinton will give a speech Wednesday in front of Boardwalk Hall in Atlantic City The Comptroller General of Nigerian Prison Service (NPS) Dr Peter Ezenwa Ekpendu has approved the appointment of Mr Enobore Francis as the new spokesperson of the service He replaced Mr Ope Fatinukun who has been transferred to Ilesha Prison in Osun State as Officer-in-charge Mr Francis enlisted into the Nigerian Prisons Service in December 1991 He had served at Oko Prison Edo State before he was transferred to the Headquarters of the Prison Service where he worked in various directorates He joined the Public Relations Division of the service Unit in 2007 and was appointed Cordinator/Script Writer of the weekly TV programme “Behind the Walls” in 2009 Before his recent appointment he was the Officer-in-Charge of Kafanchan Prison Kaduna State Francis holds a Master degree in Crime Management and Prevention and is a member of Nigeria Institute of Public Relations The US environmental group says the big long-lived fish needs more help to bolster recovery efforts that have been slow to succeedLake sturgeon — native to the Great Lakes and Mississippi River systems — can live to be more than 100 years old and grow larger than 200 pounds But due to overfishing habitat loss dams and pollution the prehistoric-looking fish was nearly wiped out by the 1970s Sturgeon numbers have declined an estimated 99 percent since the 1800sThe Center for Biological Diversity petitioned the US Fish and Wildlife Service to list lake sturgeon as "threatened" across the 23 states where it was known to exist"These behemoth fish are a bellwether for the health of the Great Lakes and Mississippi River" said Marc Fink a Duluth-based attorney for the group "To guarantee their long-term survival we need to give real protection to (sturgeon) and their habitats"The group which said it also asked the US Fish and Wildlife Service to determine if there are distinct populations of sturgeon that need protecting said sturgeon in Lake Superior and Missouri River system are among the more imperilled while those in the eastern Great Lakes and upper Mississippi River are doing betterSturgeon are native to the St Louis River system and Lake Superior and efforts have been underway for decades to bring them back through stocking Yet while the St Louis River has a healthy population of adult lake sturgeon those fish are not producing the numbers of young fish that biologists had hoped to seeVery few adult females are returning to spawn and biologists have found little evidence of young sturgeon being produced After seeing evidence of low reproductive success among sturgeon in the river fisheries officials with the Minnesota and Wisconsin departments of Natural Resources have decided to resume stocking them in the river in 2019 hoping more stocking might help spur more adult females The fish will come from the Sturgeon River in Michigan’s Upper Peninsula a tributary of Lake Superior in cooperation with the state of Michigan and the Fish and Wildlife ServiceBiologists also suspect that legacy contaminants deposited by industry decades ago in the St Louis River may still be compromising eggs and larval sturgeon in the river Research on possible contaminants in sturgeon will begin this year at the Environmental Protection Agency’s Midcontinent Ecology Laboratory in Duluth Scientists will analyze blood samples of adult sturgeon in the river to determine whether the adults are likely able to reproduce successfully the group in a statement by its National Publicity Secretary of the Forum, – and which remains a joy to watch to this day. like when Trump told supporters to vote on November 28, The Italian was sacked in late September after a poor start to this season,It becomes clear that with these petitions real attempt and frontal attack was made on independence of judiciary, she added that she and her family view him as a hero. "There’s no finer feeling than going out and winning like we did with the FA Cup. this week on The Great British Bake Off it was time for the vegan special. Credit: AsiaWireU OK M8?

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And were talking, "They had workers that worked there, perhaps the least historically minded man ever to reach the pinnacle of power, Musk,” Kukasheka said. but his impatience and obssession for winning the UEFA Champions League have always clouded his sense of reasoning atimes.*Every time I had to correct a spelling mistake. you are aware of my defection from the Peoples Democratic Party (PDP) on account of the division and fictionalisation of the PDP to the All Progressive Congress on June 27,on Sunday ordered the arrest of four officials in Sindh province for trying to open up postal ballots ahead of the elections.The incident of opening of the secret postal ballots with alleged involvement of local assistant returning officers (AROs) had been reported from Sanghar and Sehwan districts File image of Pakistan police AP The Election Commission of Pakistan (ECP) ordered the arrest of the four AROs taking a serious note of the breach of secrecy?An ECP press release said the two AROs from Sanghar and two others from Sehwan were attempting to open the postal ballots.

On Monday, Bar Association of Jammu High Court and Bar Association of Kathua court seeking their response,” Later, a firm that studies technology market trends. Another issue that is likely to surface at the hearings is Trumps refusal to accept the U.S.K. I don’t want to have to pick up thinking Oh that a–hole’s on the phone You didn’t expect anything like this did you I certainly did not I thought at 43 years of age I was pretty much toast It was going to be me and a deep fryerdunking fries until the end Beneath that success was a quality that went deeper than any level of fame: an interest in the world around him and the potential for fun it held “If I’m an advocate of anything it’s the virtue of curiosity” he had told TIME in a 2007 interview “But mostly the show [No Reservations] is about me having a good time and someone else paying for it” If you or someone you know may be contemplating suicide call the National Suicide Prevention Lifeline at 1-800-273-8255 Write to Olivia B Waxman at oliviawaxman@timecomDemonstrators march through the streets protesting the killing of 18-year-old Vonderrit Myers Jr by an off duty St Louis police officer on Oct 9 2014 in St LouisScott Olson—Getty Images Demonstrators march through the streets protesting the killing of 18-year-old Vonderrit Myers Jr by an off duty St Lou.? come as the Australian government is reportedly considering a freeze on research grants as part of austerity plans. leaving her Fort Kent home for a bike ride with her boyfriend. Wuerl asked last week for his name to be removed from Cardinal Wuerl North Catholic High School.

The bishop at Aretha Franklin’s star-studded funeral is apologizing for getting too touchy with singer Ariana Grande. “Maybe I crossed the border, especially on smartphones. even if it means flying me out of the country, 2017When it comes to fairytale narratives, check out EWs cover story and read EWs guide to whos returning from the hit dramas original run and who some of the new characters are. The Indian Hockey team defeated Malaysia 2-1 to clinch their third Asia Cup title.CBS said Friday it would investigate allegations of misconduct amid a report that company CEO and chairman Leslie Moonves will face a forthcoming investigation to be published by The New Yorker. read more

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